pH-Responsive dopamine-based nanoparticles assembled<i>via</i>Schiff base bonds for synergistic anticancer therapy
Hong Li, Yuanyuan Zhao, Yi Jia, Gang Chen, Junxia Peng, Junbai Li
Abstract
The dynamic Schiff base bond is exploited to construct monodisperse dopamine-based nanoparticles with autofluorescence and pH-sensitivity. This allows facile monitoring and pH-responsive drug release in the acidic tumor microenvironment. Anticancer drugs doxorubicin and a photosensitizer chlorin e6 are further loaded into the nanoparticles and synergistic anticancer efficacy is achieved.
Topics & Concepts
Schiff baseChemistryNanoparticleCombinatorial chemistryBase (topology)NanotechnologyDopaminePolymer chemistryMaterials scienceNeurosciencePsychologyMathematicsMathematical analysisNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryLuminescence and Fluorescent Materials