Single-nucleotide polymorphisms of <i>HLA</i> and <i>Polygonum multiflorum</i>-induced liver injury in the Han Chinese population
Wanna Yang, Lili Pang, Jiyuan Zhou, Yuanwang Qiu, Miao Liang, Shouyun Wang, Xiangzhong Liu, Kangan Tan, Wanwan Shi, Wang Gui-qiang, Feng-Qin Hou
Abstract
BACKGROUND: -induced liver injury (PM-DILI). However, little is known about the relationship between single-nucleotide polymorphisms (SNPs) and PM-DILI. AIM: To identify SNPs that indicate susceptibility to PM-DILI. METHODS: after Bonferroni correction was considered significant. RESULTS: , OR = 62.62, 95%CI: 35.91-109.20) in the Han-MHC database. CONCLUSION: , rs1055348 may become an alternative predictive biomarker of PM-DILI.
Topics & Concepts
Single-nucleotide polymorphismPolygonumLiver injuryGenotypeMedicineInternal medicineGastroenterologyBiomarkerBiologyOncologyTraditional medicineGeneticsGeneDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance MechanismsPhytochemistry and biological activity of medicinal plants