MAIT cell activation and dynamics associated with COVID-19 disease severity
Tiphaine Parrot, Jean‐Baptiste Gorin, Andrea Ponzetta, Kimia T. Maleki, Tobias Kammann, Johanna Emgård, André Perez‐Potti, Takuya Sekine, Olga Rivera‐Ballesteros, the Karolinska COVID-19 Study Group, Sara Gredmark‐Russ, Olav Rooyackers, Elin Folkesson, Lars I. Eriksson, Anna Norrby‐Teglund, Hans-Gustaf Ljunggren, Niklas K. Björkström, Soo Aleman, Marcus Buggert, Jonas Klingström, Kristoffer Strålin, Johan K. Sandberg, John Tyler Sandberg, Helena Bergsten, Niklas K. Björkström, Susanna Brighenti, Marcus Buggert, Marta Butrym, Benedict J. Chambers, Puran Chen, Martin Cornillet, Angélica Cuapio, Isabel Diaz Lozano, Majda Dzidic, Johanna Emgård, Malin Flodström‐Tullberg, Jean‐Baptiste Gorin, Sara Gredmark‐Russ, Alvaro Haroun-Izquierdo, Laura Hertwig, Sadaf Kalsum, Jonas Klingström, Efthymia Kokkinou, Egle Kvedaraite, Hans-Gustaf Ljunggren, Magda Lourda, Kimia T. Maleki, Karl‐Johan Malmberg, Jakob Michaëlsson, Jenny Mjösberg, Kirsten Moll, Jagadeeswara Rao Muvva, Anna Norrby‐Teglund, Laura M. Palma Medina, Tiphaine Parrot, Lena Radler, Emma Ringqvist, Johan K. Sandberg, Takuya Sekine, Tea Soini, Mattias Svensson, Janne Tynell, Andreas von Kries, David Wullimann, André Perez‐Potti, Olga Rivera‐Ballesteros, Christopher Maucourant, Renata Varnaitė, Mira Akber, Lena Berglin, Demi Brownlie, Marco Giulio Loreti, Ebba Sohlberg, Tobias Kammann, Elisabet Welin Henriksson, Nicole Marquardt, Kristoffer Strålin, Soo Aleman, Anders Sönnerborg, Lena Dillner, Anna Färnert, Hedvig Glans, Pontus Nauclér, Olav Rooyackers, Johan Mårtensson, Lars I. Eriksson, Björn P. Persson, Jonathan Grip, Christian Unge
Abstract
immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.