A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease
Ignacio Priéto, María Kavanagh, Luna Jiménez-Castilla, Marisa Pardines, Iolanda Lázaro, Isabel Herrero del Real, Mónica Flores‐Muñoz, Jesús Egido, Óscar López‐Franco, Carmen Gómez‐Guerrero
Abstract
, SOCS1 gene delivery decreased miR-155-5p and kidney injury in diabetic mice. Moreover, therapeutic inhibition of miR-155-5p suppressed STAT1/3 activation and alleviated albuminuria, mesangial damage, and renal expression of inflammatory and fibrotic genes. In conclusion, modulation of the miR-155/SOCS1 axis protects kidneys against diabetic damage, thus highlighting its potential as therapeutic target for DKD.
Topics & Concepts
Suppressor of cytokine signaling 1AlbuminuriaInflammationMedicineJAK-STAT signaling pathwaySTAT1Janus kinasestatmiR-155Cancer researchCytokineSTAT proteinDiabetes mellitusmicroRNASignal transductionSTAT3Internal medicineEndocrinologyBiologyCell biologyReceptorTyrosine kinaseSuppressorCancerBiochemistryGeneCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases