Transition-Metal-Free Approach to Polysubstituted Furans
Changming You, Zhenming Zhang, Yongliang Tu, Hong Tang, Yuanfeng Wang, Da Long, Junfeng Zhao
Abstract
A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.
Topics & Concepts
Transition metalDominoCombinatorial chemistryScope (computer science)Substrate (aquarium)ChemistryFunctional groupReaction conditionsDomino effectBase (topology)Cascade reactionSimple (philosophy)Organic chemistryComputational chemistryComputer scienceCatalysisMathematicsPhysicsProgramming languageEpistemologyPolymerMathematical analysisNuclear physicsGeologyPhilosophyOceanographyCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods