Biophysical and Structural Characterization of Ribulose-5-phosphate Epimerase from <i>Leishmania donovani</i>
Bandigi Narsimulu, Rahila Qureshi, Pranay Jakkula, Sayanna Are, Insaf Ahmed Qureshi
Abstract
RPE with most of the ligands exhibiting more stability than its apo form and lesser fluctuations in active site residues in the presence of ligands. Altogether, our study presents structural insights into leishmanial RPE that could provide the basis for its implication to develop potent antileishmanials.
Topics & Concepts
BiochemistryCircular dichroismRibuloseActive siteChemistryHomology modelingEnzymeBiologyRuBisCOResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsEnzyme function and inhibition