Analytical QbD for the optimization of a multimode HPLC method for the investigation of hydrochlorothiazide, diltiazem and propranolol release from 3D printed formulation
Irene Maria Samara, Marianna Ntorkou, Christos I. Gioumouxouzis, Christina Karavasili, Paraskevas D. Tzanavaras, Constantinos K. Zacharis
Topics & Concepts
Quality by DesignChromatographyChemistryHydrochlorothiazideFractional factorial designRepeatabilityCentral composite designFactorial experimentCritical quality attributesDosage formDesign of experimentsHigh-performance liquid chromatographyResponse surface methodologyMathematicsStatisticsMedicinePhysical chemistryRadiologyParticle sizeBlood pressureAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis ApplicationsAnalytical Methods in Pharmaceuticals