Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves
Fahima Mayer, Amanda L. Gunawan, Patrick Tso, Gregory W. Aponte
2020American Journal of Physiology-Gastrointestinal and Liver Physiology22 citationsDOIOpen Access PDF
Abstract
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted upon eating to lower blood sugar. GLP-1 and GIP were found to induce the secretion of substance P (SP) from cultured sensory nerves. SP enhances insulin secretion. Mesenteric lymphatic fluid (MLF) also stimulates sensory neurons in a diet-dependent manner. These studies identify new actions of GLP-1 and GIP as incretins and suggest a mechanism for sensory nerves to respond to diet through MLF.
Topics & Concepts
TRPV1Sensory systemSubstance PGlucagon-like peptide-1Internal medicineEndocrinologyGlucagonPeptideChemistryNeuropeptideReceptorMedicineNeuroscienceBiologyBiochemistryInsulinTransient receptor potential channelDiabetes mellitusType 2 diabetesIon Channels and ReceptorsBiochemical Analysis and Sensing TechniquesCardiovascular, Neuropeptides, and Oxidative Stress Research