Unfolding Discoveries in Heart Failure
Walter J. Paulus
Abstract
There are two established causes of high diastolic left ventricular stiffness: fibrosis and the rigidification of titin. A recent scientific study of a mouse model points to a third path, with implications for new experimental strategies.
Topics & Concepts
TitinMedicineHeart failureCardiologyFibrosisDiastoleStiffnessDiastolic heart failureInternal medicineStructural engineeringEngineeringMyocyteBlood pressureEjection fractionSarcomereCardiovascular Function and Risk FactorsCardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias