Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
Janak Gaire, Justin A. Varholick, Sabhya Rana, Michael D. Sunshine, Sylvain Doré, W. Brad Barbazuk, David D. Fuller, Malcolm Maden, Chelsey S. Simmons
Abstract
The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.