Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas
Hiroyuki Tomita, Kaori Tanaka, Akihiro Hirata, Hideshi Okada, Hisashi Imai, Yohei Shirakami, K Ohnishi, Shigeyuki Sugie, Hitomi Aoki, Yuichiro Hatano, Kei Noguchi, Tomohiro Kanayama, Ayumi Niwa, Natsuko Suzui, Tatsuhiko Miyazaki, Takuji Tanaka, Haruhiko Akiyama, Masahito Shimizu, Kazuhiro Yoshida, Akira Hara
Abstract
, p53, or p16 mutations or both, Fgf10-induced IPNB shows stepwise carcinogenesis, causing associated invasive carcinoma. Fgf10-induced papillary changes and progression are suppressed by the inhibition of the FGF10-FGFR2-RAS-ERK signaling pathway, demonstrating that the signal is a therapeutic target for IPNB and associated carcinoma.
Topics & Concepts
MAPK/ERK pathwayFGF10Cancer researchSTAT3Paracrine signallingAutocrine signallingFibroblast growth factorSignal transductionBiologyInternal medicineMedicineReceptorCell biologyCholangiocarcinoma and Gallbladder Cancer StudiesFibroblast Growth Factor ResearchPancreatic and Hepatic Oncology Research