PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination
Jie Wen, Kai Xiong, Abudureyimujiang Aili, Hao Wang, Yuequan Zhu, Zhengquan Yu, Xueyan Yao, Ping Jiang, Lixiang Xue, Junjie Wang
Abstract
: Our findings demonstrated a novel role for PEX5 as a miR-31-5p target and a mediator of the Wnt/β-catenin signaling and HR pathways, providing new insights into studying HCC radiation responses and implicating PEX5 and miR-31-5p as potential therapeutic targets in HCC.
Topics & Concepts
RadioresistanceCancer researchRadiosensitivityHepatocellular carcinomamicroRNAMetastasisWnt signaling pathwayCateninHBxTumor progressionCancerBiologyMedicineCell cultureSignal transductionRadiation therapyInternal medicineTransfectionCell biologyGeneticsGeneBiochemistryMicroRNA in disease regulationCircular RNAs in diseasesRNA modifications and cancer