DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy
Dongqing Li, Hang Su, Xiaolin Deng, Yuan Huang, Zihuan Wang, Jinge Zhang, Chen Chen, Zaosong Zheng, Qiong Wang, Shanchao Zhao, Zhe‐Sheng Chen, Haiyong Chen, Lina Hou, Wanlong Tan, Fei Li
Abstract
experiments confirmed that DARS2 inhibited cellular senescence and facilitated tumor progression by enhancing PINK1-mediated mitophagy. The observations from this study have provided novel insights into the multifaceted roles of DARS2-mediated mitophagy in bladder cancer. Targeting DARS2 and its regulation of mitophagy is a promising therapeutic strategy to improve the outcomes for patients with bladder cancer.
Topics & Concepts
MitophagyPINK1Bladder cancerCancer researchCancerAutophagyMedicineChemistryInternal medicineApoptosisBiochemistryEpigenetics and DNA MethylationBladder and Urothelial Cancer Treatments