Small Molecule Inhibitors of Influenza Virus Entry
Zhaoyu Chen, Qinghua Cui, Michael Caffrey, Lijun Rong, Ruikun Du
Abstract
Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.
Topics & Concepts
Lipid bilayer fusionSmall moleculeHemagglutinin (influenza)Drug discoveryComputational biologyVirusMode of actionVirologyBiologyChemistryBioinformaticsBiochemistryInfluenza Virus Research StudiesRNA and protein synthesis mechanismsinterferon and immune responses