Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC
Fang Yang, Yalei Wen, Chaofan Wang, Yuee Zhou, Yang Zhou, Zhimin Zhang, Tongzheng Liu, Xiaoyun Lu
Topics & Concepts
ChemistryKRASDegradation (telecommunications)Cancer researchPharmacologyCell biologyBiochemistryMutationBiologyTelecommunicationsGeneComputer scienceProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways