Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis
Monica Viladomiu, Manirath Khounlotham, Belgin Dogan, Svetlana Lima, Ahmed M. Elsaadi, Emre Cardakli, Jim G. Castellanos, Charles Ng, Jeremy Herzog, Alexi A. Schoenborn, Melissa Ellermann, Bo Liu, Shiying Zhang, Ajay Gulati, R. Balfour Sartor, Kenneth W. Simpson, Steven M. Lipkin, Randy Longman
Abstract
mice. Overall, these data reveal a specific and reciprocal interaction of the expansion of the CD pathobiont AIEC with ER-stress-associated ileocolitis and highlight a distinct cellular mechanism for IL-23-dependent ileocolitis.
Topics & Concepts
DysbiosisDendritic cellUnfolded protein responseCell biologyCellBiologyImmunologyChemistryCancer researchImmune systemGut floraEndoplasmic reticulumGeneticsEosinophilic EsophagitisInfant Nutrition and HealthInflammatory Bowel Disease