Serum neurofilament light chain and optical coherence tomography measures in MS
Eleonora Tavazzi, Dejan Jakimovski, Jens Kühle, Jesper Hagemeier, Osman Ozel, Murali Ramanathan, Christian Barro, Niels Bergsland, Davorka Tomic, Harald Kropshofer, David Leppert, Zuzanna Michalak, Norah S. Lincoff, Michael G. Dwyer, Ralph H. B. Benedict, Bianca Weinstock‐Guttman, Robert Zivadinov
Abstract
OBJECTIVE: To study the association between serum neurofilament light chain (sNfL) and multiple optical coherence tomography (OCT) measures in patients with MS and healthy controls (HCs). METHODS: values were adjusted for the false discovery rate. RESULTS: = 0.019). No significant associations were found in MSON eyes. CONCLUSIONS: This study confirms the ability of sNfL to detect neurodegeneration in MS and advocates for the inclusion of sNfL and OCT measures in clinical trials. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that sNfL levels were associated with MS neurodegeneration measured by OCT.