PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo
Jennie S. Campbell, Andrew J. Davidson, Henry Alfred Todd, Frederico S. L. M. Rodrigues, Abigail Elliot, Jason J. Early, David A. Lyons, Yi Feng, Will Wood
Abstract
and operates, via its band 4.1 ezrin, radixin, and moesin (FERM) domain, together with Src42A and Draper to ensure effective inflammatory cell recruitment to wounds. We show that this key role is conserved in vertebrates, because "crispant" zebrafish larvae of the Draper ortholog (MEGF10) or the Pez ortholog (PTPN21) exhibit a failure in leukocyte recruitment to wounds. This study demonstrates evolutionary conservation of inflammatory signaling and identifies MEGF10 and PTPN21 as potential therapeutic targets for the treatment of inflammatory disorders.
Topics & Concepts
Cell biologySignal transductionBiologyMoesinInflammationRadixinSchneider 2 cellsRegulatorEzrinCellBiochemistryCytoskeletonImmunologyRNA interferenceRNAGeneZebrafish Biomedical Research ApplicationsInvertebrate Immune Response MechanismsPhysiological and biochemical adaptations