eIF4F-mediated dysregulation of mRNA translation in cancer
Mehdi Amiri, Niaz Mahmood, Soroush Tahmasebi, Nahum Sonenberg
Abstract
Messenger RNA (mRNA) translational control plays a pivotal role in regulating cellular proteostasis under physiological and pathological conditions. Dysregulated mRNA translation is pervasive in cancer, in which protein synthesis is elevated to support accelerated cell growth and proliferation. Consequently, targeting the mRNA translation machinery has emerged as a therapeutic strategy to treat cancer. In this Perspective, we summarize the current knowledge of translation dysregulation in cancer, with emphasis on the eukaryotic translation initiation factor 4F complex. We outline recent endeavors to apply this knowledge to develop novel treatment strategies to combat cancer.
Topics & Concepts
ProteostasisBiologyTranslation (biology)Messenger RNAEIF4ECancerProtein biosynthesisTranslational regulationCell biologyCancer researchGeneticsGenePI3K/AKT/mTOR signaling in cancerRNA Research and SplicingRNA and protein synthesis mechanisms