Cyclohexenone Derivative and Drimane Sesquiterpenes from the Seagrass‐Derived Fungus <i>Aspergillus insuetus</i>
Zhibo Hu, Junjie Chen, Qianqian Liu, Qilin Wu, Shenhua Chen, Junjian Wang, Jing Li, Lan Liu, Zhizeng Gao
Abstract
Abstract One new cyclohexenone derivative ( 1 ), and two undescribed drimane sesquiterpenes ( 2 and 3 ), together with another seven known drimane sesquiterpenes were isolated from a seagrass‐derived fungus Aspergillus insuetus SYSU6925. Structures of these metabolites were elucidated by comprehensive spectroscopic analysis, including NMR analysis, mass spectrometry, and ECD calculations. Compounds 1 – 3 , 5 and 7 displayed weak to moderate antifungal activities towards four phytopathogenic fungi, with Minimum inhibition concentration (MIC) values range from 50 to 200 μg/mL. Compound 1 , a rare cyclohexenone derivative with n ‐propyl group exhibited more potent inhibitory activities (MIC, 50 μg/mL) against F. oxysporum than positive control (Triadimefon). Compounds 2 and 3 also exhibit potent anti‐inflammatory activities by inhibiting the production of nitric oxide (NO) in RAW264.7 cells with IC 50 values of 21.5±1.1 and 32.6±1.16 μM, respectively.