Insulin-degrading enzyme: Roles and pathways in ameliorating cognitive impairment associated with Alzheimer's disease and diabetes
Yue Tian, Guangchan Jing, Mengren Zhang
Abstract
Accumulation of amyloid-β in the central nervous system is a common feature of Alzheimer's disease (AD) and diabetes-related cognitive impairment. Since the insulin-degrading enzyme (IDE) can break down amyloid-β plaques, there is considerable interest in using this enzyme to treat both neurological disorders. In this review, we have summarized the pre-clinical and clinical research on the potential application of IDE for the improvement of cognitive impairment. Furthermore, we have presented an overview of the main pathways that can be targeted to mitigate the progression of AD and the cognitive impairment caused by diabetes.
Topics & Concepts
DiseaseDiabetes mellitusAlzheimer's diseaseCognitionNeuroscienceInsulin-degrading enzymeCognitive impairmentMedicineInsulinEnzymeBioinformaticsPsychologyBiologyInternal medicineEndocrinologyBiochemistryAlzheimer's disease research and treatmentsNatural Antidiabetic Agents StudiesNeurological Disorders and Treatments