Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
Juan Tur, Selma Pereira‐Lopes, Tania Vico, Eros Marín, Juan Pablo Muñoz, Maribel Hernández-Alvarez, Père-Joan Cardona, António Zorzano, Jorge Lloberas, Antonio Celada
Abstract
mice fail to be protected from Listeria, Mycobacterium tuberculosis, or LPS endotoxemia. These results reveal an unexpected contribution of Mfn2 to ROS production and inflammation in macrophages.
Topics & Concepts
MFN2MFN1Cell biologyMitochondrial ROSReactive oxygen speciesmitochondrial fusionInflammationMitochondrionPhagocytosisAutophagyMacrophageLipopolysaccharideChemistryBiologyImmunologyApoptosisBiochemistryMitochondrial DNAGeneIn vitroMitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research