Poly(succinimide) nanoparticles as reservoirs for spontaneous and sustained synthesis of poly(aspartic acid) under physiological conditions: potential for vascular calcification therapy and oral drug delivery
Hossein Adelnia, Idriss Blakey, Peter J. Little, Hang T. Ta
Abstract
calcification of smooth muscle cells. This was attributed to the chelation of calcium ions to PASP, thereby inhibiting calcium deposition, because under cell culture conditions PSI NPs serve as reservoirs for the sustained synthesis of PASP. Overall, this study sheds light on the preparation and features of biocompatible and biodegradable PSI-based NPs and paves the way for further research to discover as-yet unfulfilled potential of this polymer in the form of nanoparticles.
Topics & Concepts
SuccinimideNanoparticleDissolutionAspartic acidMaterials scienceSuccinimidesDrug deliveryChemical engineeringNanotechnologyChemistryOrganic chemistryBiochemistryAmino acidEngineeringbiodegradable polymer synthesis and propertiesBone Tissue Engineering MaterialsPolymer Surface Interaction Studies