Evaluation of focused beam reflectance measurement (FBRM) for monitoring and predicting the crystal size of carbamazepine in crystallization processes
David Acevedo, Wei-Lee Wu, Xiaochuan Yang, Naresh Pavurala, Adil Mohammad, Thomas O’Connor
Abstract
Pharmaceutical crystallization affects the properties of APIs as it determines the purity and crystal size distribution, among other attributes. This work presents two CLD–CSD models, theoretical and empirical, for a model compound.
Topics & Concepts
CrystallizationCrystal (programming language)ReflectivityBiological systemMaterials scienceBeam (structure)Work (physics)Process engineeringOpticsChemistryComputer scienceThermodynamicsOrganic chemistryPhysicsBiologyEngineeringProgramming languageCrystallization and Solubility StudiesCrystallography and molecular interactionsAnalytical Chemistry and Chromatography