Increased mTOR and suppressed autophagic flux in the heart of a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease
Daniel Atwood, Deepak Pokhrel, Carolyn Nicole Brown, Sara J. Holditch, Dheevena M Bachu, Andrew Thorburn, Katharina Hopp, Charles L. Edelstein
Topics & Concepts
AutophagymTORC1PI3K/AKT/mTOR pathwayMechanistic target of rapamycinBiologyCell biologyRegulatorEndocrinologyInternal medicineAutophagosomeLysosomeRPTORBECN1MedicineSignal transductionBiochemistryApoptosisGeneEnzymeGenetic and Kidney Cyst DiseasesAutophagy in Disease and TherapyBiomedical Research and Pathophysiology