An adult zebrafish model for adherent-invasive Escherichia coli indicates protection from AIEC infection by probiotic E. coli Nissle
Dhrubajyoti Nag, Dustin Farr, Saumya Raychaudhuri, Jeffrey H. Withey
Abstract
Nissle 1917 (EcN) was tested as a therapeutic and prophylactic against AIEC infection and reduced AIEC colonization, tissue damage, and pro-inflammatory responses in zebrafish. Furthermore, EcN diminished the propionic-acid-augmented hyperinfection of AIEC in zebrafish. Thus, this study shows the efficacy of EcN against AIEC in an AIEC-zebrafish model.
Topics & Concepts
ZebrafishBiologyMicrobiologyColonizationEscherichia coliProbioticPathogenTumor necrosis factor alphaInflammationVirologyImmunologyBacteriaGeneBiochemistryGeneticsImmune Response and InflammationImmune responses and vaccinationsEscherichia coli research studies