Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy
Chengyong Wu, Lele Zhang, Zhilan Zhou, Lun Tan, Zhijia Wang, Cuiyu Guo, Yuxi Wang, Yuxi Wang
Topics & Concepts
ChemistryPyrimidineStereochemistryTubulinCancerCancer therapyCombinatorial chemistryPharmacologyMicrotubuleInternal medicineGeneticsMedicineBiologySynthesis and biological activitySynthesis and Biological EvaluationSynthesis and Reactions of Organic Compounds