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DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

Roshni Roy, Senthilkumar Ramamoorthy, Benjamin D. Shapiro, Mary Kaileh, Dena Hernández, Dimitra Sarantopoulou, Sampath Arepalli, Sören Boller, Amit Singh, Arsun Bektas, Jae‐Kwan Kim, Ann Zenobia Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, Robert P. Wersto, William H. Wood, Yulan Piao, Kevin G. Becker, Christopher Coletta, Supriyo De, Jyoti Misra Sen, Alexis Battle, Nan‐ping Weng, Rudolf Grosschedl, Luigi Ferrucci, Ranjan Sen

2021Immunity65 citationsDOIOpen Access PDF

Topics & Concepts

BiologyDNA methylationEpigeneticsEpigenomicsReprogrammingImmune systemTranscription factorCell typeGeneticsContext (archaeology)Lineage (genetic)Acquired immune systemChromatinCellGeneComputational biologyGene expressionPaleontologyEpigenetics and DNA MethylationImmune Cell Function and InteractionImmune cells in cancer
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity | Litcius