Electrochemical Oxidative Difunctionalization of Alkenes to Access α-Oxygenated Ketones
Changhui Dai, Yijie Shen, Yifan Wei, Ping Liu, Peipei Sun
Abstract
Dioxygenation of alkenes was developed by the combination of electrochemical synthesis and aerobic oxidation, leading to easy accessibility of α-oxygenated ketones in an eco-friendly fashion. Using air as the oxygen source and the absence of transition metals were the critical features of this protocol. A wide range of alkenes and N-hydroxyimides were found to be compatible and provided α-oxygenated ketones in moderate to high yields.
Topics & Concepts
ChemistryElectrochemistryOxidative phosphorylationMolecular oxygenOxygenOrganic chemistryCombinatorial chemistryElectrodePhysical chemistryBiochemistryRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods