Enhanced response to PD-L1 silencing by modulation of TME via balancing glucose metabolism and robust co-delivery of siRNA/Resveratrol with dual-responsive polyplexes
Jia Li, Yan Gao, Tong Zhou, Xiuli Zhao, Haiyang Hu, Dawei Chen, Mingxi Qiao
Topics & Concepts
Downregulation and upregulationTumor microenvironmentGlycolysisOxidative phosphorylationCell biologyCancer researchChemistryBiologyImmune systemBiochemistryMetabolismImmunologyGeneNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics