MWCNT-mediated combinatorial photothermal ablation and chemo-immunotherapy strategy for the treatment of melanoma
Xiaoxiao Wang, Binhan Li, Huimin Jing, Xia Dong, Xigang Leng
Abstract
T cells in the spleen, draining lymph nodes and tumor tissues. The regimen promoted TAM shifting from M2 to M1 while decreasing the number of Treg cells in the tumor microenvironment, which probably contributed to the enhanced anti-tumor efficacy of the regimen. Hopefully, the invented strategy might find potential applications for the therapy of melanoma in the future.
Topics & Concepts
Photothermal therapyMelanomaImmunotherapyCancer researchImmune systemChemotherapyTumor ablationMaterials sciencePhotothermal effectAntigenAblationMedicineNanotechnologyImmunologyInternal medicineNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers