The activation of GPER inhibits cells proliferation, invasion and EMT of triple-negative breast cancer via CD151/miR-199a-3p bio-axis.
Ruiyan Huang, Junbai Li, Feng Pan, Baofan Zhang, Yufeng Yao
Abstract
Collectively, the activation of GPER inhibits cells proliferation, invasion and EMT of triple-negative breast cancer via CD151/miR-199a-3p bio-axis. This study provides a novel intervention target for the treatment of breast cancer cells and a fresh idea for the clinical therapy of breast cancer.
Topics & Concepts
GPERAngiogenesisCell growthCancer researchTriple-negative breast cancerHippo signaling pathwayTransfectionViability assayCell migrationSignal transductionCarcinogenesisBiologyCellEstrogen receptorCell biologyChemistryCancerCell cultureBreast cancerGeneticsHippo pathway signaling and YAP/TAZCell Adhesion Molecules ResearchReceptor Mechanisms and Signaling