The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
Johannes Rudolph, Uma M. Muthurajan, Megan Palacio, Jyothi Mahadevan, Genevieve Roberts, Annette H. Erbse, Pamela N. Dyer, Karolin Luger
Topics & Concepts
BiologyPARP1DNADNA damageNAD+ kinaseDNA-binding domainCell biologyBiophysicsPoly ADP ribose polymeraseBiochemistryPolymeraseEnzymeTranscription factorGenePARP inhibition in cancer therapyDNA Repair MechanismsCell death mechanisms and regulation