The Rise of Adaptive Platform Trials in Critical Care
The PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators
Abstract
As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.
Topics & Concepts
MedicineIntensive care medicineCritical illnessIntensive careCritically illStatistical Methods in Clinical TrialsHealth Systems, Economic Evaluations, Quality of LifeMeta-analysis and systematic reviews