Palladium Catalyzed Enantioselective Hayashi–Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-dihydrocoumarins
Jixing Lai, Chen Yang, René Csük, Baoan Song, Shengkun Li
Abstract
The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions, and accommodation of electron-withdrawing arylboronic acids.
Topics & Concepts
ChemistryArylEnantioselective synthesisPalladiumCatalysisScope (computer science)Substrate (aquarium)Combinatorial chemistryOrganic chemistryGeologyAlkylProgramming languageComputer scienceOceanographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Biological Activity