E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing
De Chen, Yanjie Wang, Ruixun Lu, Xiaofeng Jiang, Xinhui Chen, Nan Meng, Min Chen, Shan Xie, Guang‐Rong Yan
Abstract
Our study identifies ZFP91 as a tumor suppressor of hepatocarcinogenesis and HCC metabolism reprogramming and proposes it as a novel prognostic biomarker and therapeutic target of HCC.
Topics & Concepts
Ubiquitin ligaseCancer researchGene knockdownBiologyUbiquitinReprogrammingWestern blotMetastasisMolecular biologyCell growthCancerCellCell cultureBiochemistryGeneGeneticsRNA modifications and cancerUbiquitin and proteasome pathwaysRNA Research and Splicing