Genetic Diversity of Polymyxin-Resistance Mechanisms in Clinical Isolates of Carbapenem-Resistant Klebsiella pneumoniae: a Multicenter Study in China
Ziyao Li, Xinmeng Liu, Zichen Lei, Chen Li, Feilong Zhang, Yongli Wu, Xinrui Yang, Jiankang Zhao, Yulin Zhang, Yanning Hu, Fang‐Fang Shen, Pingbang Wang, Junwen Yang, Yulei Liu, Binghuai Lu
Abstract
Polymyxin-resistant CRKP is a serious public health threat whose resistance mechanisms should be under continuous surveillance. Here, we collected 662 nonduplicate CRKP strains across China to identify the carbapenemase and polymyxin resistance genes and epidemiological features.
Topics & Concepts
PolymyxinKlebsiella pneumoniaeMicrobiologyPolymyxin BAntibiotic resistanceEnterobacteriaceaeEpidemiologyChinaMolecular epidemiologyBiologyMulticenter studyCarbapenemGenetic diversityVirologyMedicineEnvironmental healthGeneticsGeneGenotypeAntibioticsGeographyInternal medicinePopulationEscherichia coliRandomized controlled trialArchaeologyAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPharmaceutical and Antibiotic Environmental Impacts