Polymorphs and hydrates of the anticancer drug erlotinib: X-ray crystallography, phase transition and biopharmaceutical studies
Shridhar H. Thorat, Christy P. George, Parth S. Shaligram, P. R. Suresha, Rajesh G. Gonnade
Abstract
The anticancer drug erlotinib revealed two polymorphs and two hydrates. The metastable polymorph and hydrates converted to the stable polymorph, which displayed solution-mediated transformation into the monohydrate at the lowest water activity.
Topics & Concepts
ErlotinibCrystallographyMetastabilityDrugChemistryPhase transitionBiopharmaceuticalPhase (matter)Polymorphism (computer science)Materials sciencePharmacologyOrganic chemistryBiochemistryEpidermal growth factor receptorMedicineThermodynamicsBiologyGeneticsReceptorPhysicsGenotypeGeneEnzyme Structure and FunctionEnzyme function and inhibitionChemical Reactions and Isotopes