Sensitizing chemotherapy for glioma with fisetin mediated by a microenvironment-responsive nano-drug delivery system
Wan-Yu Wang, Yuanyuan Zhang, Yue Jian, He Shi, Jiagang Liu, Yongzhong Cheng, Songping Zheng, Zhiyong Qian, Xiang Gao, Xiang Wang
Abstract
. Our study provides a new strategy to overcome drug resistance by utilizing a natural product to sensitize conventional chemotherapeutics with well-designed targeted nanodelivery systems for cancer treatment.
Topics & Concepts
Tumor microenvironmentNanocarriersDrug deliveryIn vivoGliomaCancer cellNanomedicineCancer researchPharmacologyFisetinDrugDoxorubicinChemistryChemotherapyCancerNanotechnologyMaterials scienceNanoparticleMedicineBiologyAntioxidantBiochemistryTumor cellsBiotechnologySurgeryInternal medicineFlavonoidNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryFerroptosis and cancer prognosis