CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons
Danny McSweeney, Rafael Gabriel, Kang Jin, Zhiping P. Pang, Bruce J. Aronow, ChangHui Pak
Abstract
KO iNs display severe defects in synaptic transmission and synchronized network activity without compromising neuronal morphology and synapse numbers. In the developing human cortical excitatory neurons, CASK functions to promote both structural integrity and establishment of cortical excitatory neuronal networks. These results lay the foundation for future studies identifying suppressors of such phenotypes relevant to human patients.
Topics & Concepts
CASKNeuroscienceExcitatory postsynaptic potentialSynapseBiologySynaptogenesisNeurotransmissionInhibitory postsynaptic potentialGeneticsReceptorHippo pathway signaling and YAP/TAZGenetics and Neurodevelopmental DisordersCRISPR and Genetic Engineering