NAD<sup>+</sup> precursors promote the restoration of spermatogenesis in busulfan-treated mice through inhibiting Sirt2-regulated ferroptosis
Yanqin Feng, Xuan Liu, Ning Zuo, Meilling Yu, Wen-Meng Bian, Baoquan Han, Zhongyi Sun, Massimo De Felici, Wei Shen, Lan Li
Abstract
protects spermatogenesis against ferroptosis, probably through SIRT2 dependent mechanisms. This underscores the considerable potential of Npre supplementation as a feasible strategy for preserving or restoring spermatogenesis in specific conditions of male infertility and as adjuvant therapy to preserve male fertility in cancer patients receiving sterilizing treatments.
Topics & Concepts
NAD+ kinaseSIRT2BusulfanSpermatogenesisChemistryPharmacologyCell biologyCancer researchSirtuinMedicineBiologyBiochemistryInternal medicineStem cellEnzymeHematopoietic stem cell transplantationMicroRNA in disease regulationFerroptosis and cancer prognosisCircular RNAs in diseases