Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7
Courtney Fisher, Matteo Pavan, Veronica Salmaso, Robert F. Keyes, Tina C. Wan, Balaram Pradhan, Zhan‐Guo Gao, Brian C. Smith, Kenneth A. Jacobson, John A. Auchampach
Topics & Concepts
ChemistryStereochemistryAllosteric regulationTransmembrane domainAmine gas treatingCrystallographyDocking (animal)Helix (gastropod)Molecular dynamicsBinding siteMolecular switchMoleculeAmino acidReceptorComputational chemistryBiochemistrySnailMedicineBiologyEcologyNursingOrganic chemistryReceptor Mechanisms and SignalingAdenosine and Purinergic SignalingPharmacological Receptor Mechanisms and Effects