Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts
Florian Perner, Jayant Y. Gadrey, Yijun Xiong, Charlie Hatton, Benjamin K. Eschle, Andreas Weiss, Frédéric Stauffer, Christoph Gaul, Ralph Tiedt, Jennifer A. Perry, Scott A. Armstrong, Andrei V. Krivtsov
Abstract
Publisher's Note: There is a Blood Commentary on this article in this issue.
Topics & Concepts
MethyltransferaseCancer researchHistoneHistone methyltransferasePharmacologyMedicineChemistryBiologyGeneticsMethylationDNAEpigenetics and DNA MethylationAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research