The metabolic genomic atlas reveals potential drivers and clinically relevant insights into the etiology of esophageal squamous cell carcinoma
Xuesong Liu, Ruoxi Hong, Peina Du, Di Yang, Meibo He, Qingnan Wu, Lin Li, Yan Wang, Jie Chen, Qingjie Min, Jinting Li, Weimin Zhang, Qimin Zhan
Abstract
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers globally, with a poor prognosis and ambiguous therapy target. As a hallmark of cancer, metabolism reprogramming plays a critical role in the development of ESCC; however, the genomic alterations underlying this reconfiguration are still largely unknown. Methods: We have comprehensively studied the metabolic genomic variations in an integrated ESCC cohort of 490 patients and characterized the somatic alterations associated with various metabolic pathways.
Topics & Concepts
Somatic cellBiologyMalignancyCDKN2BCancerBioinformaticsDiseaseCancer researchGeneGeneticsMedicineInternal medicineCDKN2ARNA modifications and cancerEpigenetics and DNA MethylationCancer, Hypoxia, and Metabolism