Hydrogen-bonded supramolecular micelle-mediated drug delivery enhances the efficacy and safety of cancer chemotherapy
Chih‐Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu‐Hsuan Chiao, Chih‐Wei Chiu, Juin-Yih Lai
Abstract
Multiple hydrogen-bonded supramolecular polymers tend to form stable spherical micelles with oppositely charged anticancer drugs in biological environments, which improves cellular drug uptake and more effectively induces apoptosis in cancer cells.
Topics & Concepts
MicelleDrugSupramolecular chemistryDrug deliveryPolymerChemistryApoptosisCancer cellHydrogenChemotherapyCancerHydrogen bondCombinatorial chemistryNanotechnologyBiophysicsCancer researchMaterials sciencePharmacologyMedicineBiochemistryOrganic chemistryMoleculeBiologyInternal medicineAqueous solutionNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersSupramolecular Chemistry and Complexes