Approximation of a Microbiome Composition Shift by a Change in a Single Balance Between Two Groups of Taxa
Vera Odintsova, Natalia Klimenko, Alexander Tyakht
Abstract
The method proposed here extends the range of compositional methods providing interpretation of classical statistical tools applied to data converted to the ILR coordinates. It provides a strictly optimal solution in several special cases. The approach is universally applicable to compositional data of any nature, including microbiome data sets.
Topics & Concepts
Compositional dataPrincipal component analysisCovariatePartial least squares regressionMetagenomicsRegressionComputer scienceMicrobiomeMathematicsStatisticsData miningEconometricsChemistryBiologyBioinformaticsBiochemistryGeneGeochemistry and Geologic MappingHydrocarbon exploration and reservoir analysisMetabolomics and Mass Spectrometry Studies