Development of Early-Life Gastrointestinal Microbiota in the Presence of Antibiotics Alters the Severity of Acute DSS-Induced Colitis in Mice
Xiaojun Li, Yu Ren, Jie Zhang, Chunhui Ouyang, Chunlian Wang, Fanggen Lu, Yani Yin
Abstract
This study investigated resident microbiota in the whole gastrointestinal (GI) tract to explore gut microbiota development in early life and found that early-life antibiotic exposure exacerbated alterations in gut microbiota and murine dextran sulfate sodium (DSS)-induced colitis. Furthermore, the presence of bacteria in the GI tract of mice before birth and the importance of the lactation period in GI microbiota development were confirmed.
Topics & Concepts
Gut floraColitisBiologyGastrointestinal tractAntibioticsLactationDysbiosisMicrobiologyImmunologyPhysiologyPregnancyGeneticsBiochemistryGut microbiota and healthGastrointestinal motility and disordersClostridium difficile and Clostridium perfringens research