Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy
Yanlan Liu, Kelong Ai, Jianhua Liu, Mo Deng, Yangyang He, Lehui Lu
Abstract
A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.
Topics & Concepts
Photothermal therapyBiocompatibilityMaterials scienceMelaninNanotechnologyIn vivoBiopolymerColloidDopamineBiomedical engineeringBiophysicsPolymerChemistryBiologyMedicineBiochemistryComposite materialOrganic chemistryNeuroscienceBiotechnologyMetallurgyNanoplatforms for cancer theranosticsGold and Silver Nanoparticles Synthesis and ApplicationsExtracellular vesicles in disease