Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)
Bing Zhao, Qianqian Liang, Hongmei Ren, Xinhui Zhang, Yang Wu, Kun Zhang, Liying Ma, Yi‐Chao Zheng, Hong‐Min Liu
Topics & Concepts
DemethylaseChemistryPyrazoleHistoneHistone H3IC50Cancer researchBiochemistryStereochemistryIn vitroGeneBiologyHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationPeroxisome Proliferator-Activated Receptors