Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
Kevin M. Tharp, Kelly Kersten, Ori Maller, Greg A. Timblin, Connor Stashko, Fernando P. Canale, Rosa E. Menjivar, Mary-Kate Hayward, Ilona Berestjuk, Johanna ten Hoeve, Bushra Samad, Alastrair J. Ironside, Marina Pasca di Magliano, Alexander Muir, Roger Geiger, Alexis J. Combes, Valerie M. Weaver
Topics & Concepts
ReprogrammingTumor microenvironmentFunction (biology)Cancer researchBreast cancerCell biologyCytotoxic T cellCD8Cancer immunotherapyCancerChemistryImmune systemBiologyImmunologyCellImmunotherapyTumor cellsMedicineInternal medicineBiochemistryIn vitroImmune cells in cancerCancer Cells and MetastasisCancer Immunotherapy and Biomarkers